• • 上一篇    下一篇

非冬眠期达乌尔黄鼠对低温的适应性产热

张淑珍, 李庆芬, 黄晨西   

  1. 北京师范大学生物系
  • 出版日期:2006-06-29 发布日期:2008-07-07

ADAPTIVE THERMOGENESIS OF DAURIAN GROUND SQUIRREL (CITELLUS DAUR ICUS) DURING COLD ACCL IMATION IN SUMMER

ZHANG Shuzhen ,LI Qingfen, HUANG Chenxi   

  • Online:2006-06-29 Published:2008-07-07

摘要:  达乌尔黄鼠在夏季冷驯化低温环境下(5±1℃) 暴露4周后, 导致脂肪积累的抑制; 其静
止代谢率(RMR) 和非颤抖性产热(N ST) 分别提高了12% 和85%; 肝脏线粒体的蛋白含量、状态3呼吸和细胞色素C 氧化酶活力分别提高了22%、42% 和48% , 表明在低温环境下肝脏线粒体产热能力的增强是RMR 提高的细胞学机制之一; 褐色脂肪组织(BAT) 的重量、蛋白含量、细胞色素C 氧化酶活力和A2磷酸甘油氧化酶活力极显著提高, 表明在低温环境下BAT是达乌尔黄鼠的主要产热器官, BAT 产热能力的增强是NST 提高的重要细胞学机制之一。冷驯化没有引起达乌尔黄鼠血清T3、T4含量的变化。

关键词: 达乌尔黄鼠, 冷驯化, 肝脏, 褐色脂肪组织

Abstract:  Af ter four weeks of cold acclimation (5±1℃) in summer fat accumulation was inhibited in Daurian ground squirrel (Citellus dauricus). Resting metabolic rat (RMR )and non-shivering thermogenesis (NST ) showed an increase of 12% and 85% respectively. The protein conten t, state-3 respiration and cytochrome Coxidase activity of liver mitochondria showed an increase of 22% , 42%and 48% respectively, suggesting the enhancement of thermogenic capacity of liver was one of the celluar mechanisms of the rise of RMR. The weight, protein content, activity of cytochrome Coxidase and ā-phosphoglycerol oxidase of brown adipose tissue BAT ) were markedly improved, suggesting that BAT is the main thermogenenic organ and the enhancement of capacity of BAT thermogenesis is one of the celluarm echanisms of the increase of NST during cold acclimation. Serum T3 and T4 concentration didnot change obviously during cold acclimation in Daurian ground quirrel.
  

Key words: Daurian ground squirrel, Cold acclimation, Liver, Brownadipose tissue