关键词: 米非司酮, 不育控制, 鼠害, 繁殖

Abstract: In order to determine the suitable dose of mifepristone for use in pest rodent control,female mice were fed with mifepristone at different doses every two weeks by gastric gavage. Reproductive parameters were determined during and after the treatments. There was a dose-dependent relationship between the anti-fertility effect of mifepristone and the doses of mifepristone during the administration. Reproduction was not inhibited significantly when the dose of mifepristone was below 1. 25 mg / kg,while the reproductive rate was reduced at 2. 5 mg/ kg. When the dose of mifepristone was 5 mg /kg,not only was the reproductive rate reduced,but the litter size also decreased significantly. Reproduction was inhibited completely when the dose of mifepristone was more than 10 mg/ kg. After cessation of administration,there was a dose-effect relationship between female mices’ reproduction and the doses of mifepristone. After stopping treatment,reproductive capabilities of mice gradually returned to a level that was the same as that of the control group. When considering the costs and benefits of rodent control,the dose of mifepristone used should be based on the dose which just inhibits reproduction completely.

Key words: Fertility control, Mifepristone, Reproduction, Rodent pest