Abstract: Epidemiological,clinical and pathological characters were observed and analyzed in fur-bearing animal populations suspected of canine distemper (CD)in Shandong,Hebei,Liaoning and Jiangsu Provinces from June to October, 2006. The tissue samples were used to isolate and identify bacteria and detect CDV specific nucleic acid,and pathological characters of liver,spleen,lung,brain,bladder were observed. The results showed that this CD was mainly caused by allocation and transportation of raccoon dogs and minks carrying CDVs. Pathological lesions were characterized as haemorrage of whole body tissues,and the severity levels to CDV from highest to lowest were raccoon dog,fox and mink,respectively. Histopathology featured alveolar wall thickening;inflammatory cell infiltration;eosinophilic global inclusion bodies forming in alveolar epithelial cell and urothelial cell intracytoplasm;bronchi epithelium deformation,necrosis and defluvium;lymphocyte infiltrating;apyogenous demyelination encephalitis emergence;distinct haemorrhage and necrosis in spleen,kidney, heart,liver,stomach and intestinal tract. Pathological comparison of lung,liver,brain,kidney and bladder indicated that there were no obviously differences apart from the pathological changes between minks,fox and raccoon dogs. However, differences of pathological lesions existed in the same species of animals depending on the course,the type,and complications of disease.

Key words: Canine distemper, Fur-bearing animal, Histopathology, Pathological lesion

摘要： 对2006 年6 ～10 月山东、河北等地区的部分毛皮动物养殖场发生疑似犬瘟热的疫情进行了流行病学、临
床症状以及剖检病变观察和分析,对采集的病料进行了细菌分离鉴定、病毒特异性核酸检测,并选取肝、脾、
肺、心、脑、膀胱和胃进行了病理组织学检查。结果表明,这起疫情主要是由携带CDV 的貉、貂调运而促进病
毒传播感染引起。发病动物剖检病变以全身脏器出血性变化为特征,病情及病变严重程度依次为貉> 狐狸> 水
貂。病理学变化特征为肺泡壁增厚,大量炎性细胞浸润,且在脱落肺泡上皮细胞、膀胱上皮细胞胞浆内偶见嗜
酸性的球形包涵体,支气管上皮变形、坏死、脱落,淋巴细胞浸润;非化脓性脱髓鞘性脑炎;脾脏、肾脏、心
脏、肝脏、胃和肠道有不同程度出血、坏死等病变。通过对发病狐、貉、貂的肺、肝、脑、膀胱等脏器病理学
比较,在病变程度上水貂与狐狸、貉有差异。但是同一种动物,依病程、病型及有无并发症等因素,病理学变
化也存在差异。

关键词: 犬瘟热, 组织病理, 病理变化, 毛皮动物