Abstract: The expression of estrogen receptor (ER) in the hypothalamus of Macaques (Macaca mulatta) was studied by
using inmunohistochemical SABC. We found that the ER immuno-positive neurons were mainly distributed in periventricular gray matter,nucleus ventromedialis,nucleus paraventricularis,nucleus arcuate of the hypothalamus,and the labeled ER were mainly found in the nucleus and cytoplasma. Compared with young Macaques,the expression intensity and number of ER positive neurons in each of the hypothalamic nuclei in the senile Macaques (n = 4)were significantly or extremely significant lower than those in the young ones (P < 0.05 or P < 0.01). These results suggest that the expression of ER in the senile Macaques is significant lower than that in the young Macaques,which may be caused by estrogen-hunger.

Key words: Estrogen receptor (ER), Hypothalami, Immunohistochemical SABC, Macaque (Macaca mulatta), Senile

摘要： 为了观察老年猕猴下丘脑中雌激素受体的表达及变化情况,运用免疫组织化学SABC 法,对青年和老年猕
猴下丘脑雌激素受体的表达特点进行了研究。结果发现,雌激素受体免疫阳性细胞主要分布于下丘脑的室周灰
质、室旁核、腹外侧核、腹内侧核、弓状核等,雌激素受体阳性产物主要定位于细胞核和细胞质中。与青年猕
猴比较,老年猕猴下丘脑各个核团的雌激素受体在表达强度及阳性细胞数量上均显著或极显著低于青年猕猴
(P<0.05 或 P<0.01)。表明,老年猕猴下丘脑雌激素受体的表达显著低于青年猕猴,可能为老年猕猴雌激素缺
乏所致。

关键词: 雌激素受体, 免疫组织化学SABC, 下丘脑, 老年, 猕猴