%0 Journal Article %A CHEN Zhengli %A CHENG Anchun %A LUO Qihui %A ZENG Wen %T Comparison of estrogen receptor expression in hypothalamus of young and senile Macaques (Macaca mulatta) %D 2010 %R %J ACTA THERIOLOGICA SINICA %P 177-181 %V 30 %N 2 %X The expression of estrogen receptor (ER) in the hypothalamus of Macaques (Macaca mulatta) was studied by
using inmunohistochemical SABC. We found that the ER immuno-positive neurons were mainly distributed in periventricular gray matter,nucleus ventromedialis,nucleus paraventricularis,nucleus arcuate of the hypothalamus,and the labeled ER were mainly found in the nucleus and cytoplasma. Compared with young Macaques,the expression intensity and number of ER positive neurons in each of the hypothalamic nuclei in the senile Macaques (n = 4)were significantly or extremely significant lower than those in the young ones (P < 0.05 or P < 0.01). These results suggest that the expression of ER in the senile Macaques is significant lower than that in the young Macaques,which may be caused by estrogen-hunger.
%U http://www.mammal.cn/EN/abstract/article_2326.shtml