%0 Journal Article %A CAI Luna %A LIU Shuai %A LIU Xinyu %A LV Zheng %A MEN Liyuan %A PENG Xia %A SONG Shiyi %A YANG Ming %T Differential gene expression associated with glycometabolism in the white adipose tissue during fattening and hibernation in Daurian ground squirrel (Spermophilus dauricus) %D 2015 %R %J ACTA THERIOLOGICA SINICA %P 422-430 %V 35 %N 4 %X In order to study the mechanism of glycometabolism in the fattening progress and hibernation in fat-storing hibernators, we used next generation transcriptome sequencing technology (RNA-Seq) to detect differentially expressed genes associated with glycometabolism in the white adipose tissue, aldolase, enolase and so on; FBPase gene expression was up-regulated 9.6-fold and some other genes such as phosphoenolpyruvate carboxykinase, aldolase, citrate synthase at were down-regulated 1.2-fold to 2-fold Finished-Fattening expression levels of genes was significantly reduced in Hibernation, including hexokinase, aldolase, isocitrate dehydrogenase, 6-phosphogluconate and so on. It suggests that the increase in expression of hexokinase and other enzymes could be directly linked to the enhancement of glycometabolism at Rapid-Fattening in the Daurian ground squirrel; the down-regulation of aldolase and citrate synthase genes could be the reason for weakened glycometabolism at Finished-Fattening; the low expression of hexokinase, pyruvate dehydrogenase and other genes may be part of a general mechanism to coordinate glycometabolism reduction to an extreme level in hibernation. The initial regulation for glycometabolism pathways at the molecule level had been started in the active season before hibernation in the Daurian ground squirrel. compared with Rapid-Fattening ; of the Daurian ground squirrel (Spermophilus dauricus) and measured blood glucose at four physiological stages: Initial-Fattening, Rapid-Fattening, Finished-Fatteningene expression of fructose-1,6-bisphosphatase(FBPase) was down-regulatedcompared with Initial-Fattening, included hexokinase (HK) 8.3-fold and a sampling of genes that were up-regulated at Rapid-Fattening and Hibernation. Results show that there were no differences in blood glucose among stages of Initial-Fattening, Rapid-Fattening and Finished-Fattening but all were significantly higher than during Hibernation; G %U http://www.mammal.cn/EN/abstract/article_3059.shtml