兽类学报 ›› 2022, Vol. 42 ›› Issue (3): 339-344.DOI: 10.16829/j.slxb.150592

• 研究简报 • 上一篇    下一篇

半乳甘露聚糖检测在圈养海洋动物曲霉病早期诊断的应用

董贵信1,3, 张德录2, 黄泽林2, 张孝敏2, 梁淑余2, 陈小芬2, 沈博2, 张鹏1,3   

  1. 1. 广东长隆集团有限公司, 广州 511400;
    2. 珠海长隆海洋王国, 珠海 519000;
    3. 广东华南珍稀野生动物物种保护中心, 珠海 519031)
  • 收稿日期:2021-07-29 修回日期:2022-02-23 发布日期:2022-06-02
  • 通讯作者: 董贵信,E-mail:caesar@chimelong.com
  • 作者简介:董贵信(1963-),男,博士,高级兽医师,广东长隆集团有限公司首席动植物官,主要从事野生动物保育与科普研究.

Clinical application of galactomannan test in early diagnosis of aspergillosis in captive marine animals

DONG Guixin1,3, ZHANG Delu2, HUANG Zelin2, ZHANG Xiaomin2, LIANG Shuyu2, CHEN Xiaofen2, SHEN Bo2, ZHANG Peng1,3   

  1. 1. Guangdong Chimelong Group, Co., Ltd., Guangzhou 511400, China;
    2. Chimelong Ocean Kingdom, Zhuhai 519000, China;
    3. Guangdong South China Rare Wild Animal Species Conservation Center, Zhuhai 519031, China
  • Received:2021-07-29 Revised:2022-02-23 Published:2022-06-02

关键词: 半乳甘露聚糖检测, 曲霉病, 海洋动物, 感染早期, 临床应用

Abstract: Aspergillosis is one of the most common diseases in captive marine animals, and the early diagnosis of infection has not been reported. Galactomannan (GM) test is a good method for Aspergillus detection, which has a high clinical value in the early diagnosis of human medical Aspergillus infection, and can significantly improve the detection rate of Aspergillus patients. The purpose of this study was to investigate the clinical value of the GM test in the early diagnosis of aspergillosis infection in captive marine animals. The serum of 106 captive marine animals was tested for GM antigen, 25 were positive and 81 were negative. The dynamic changes of GM antigen levels before and after antifungal treatment were detected in 21 positive individuals. In addition, clinical data of the infected animals were collected for statistical analysis, and the value of GM detection for the early diagnosis of Aspergillus infection in captive marine animals was evaluated. When single I ≥ 0. 7 was used as the positive threshold for sea mammals and single I ≥ 1. 2 as the positive threshold for seabirds, the results showed that the sensitivity and specificity of the test were 91% for sea mammals and 94% for seabirds. This study shows that the GM test can effectively reflect the degree of Aspergillus infection in captive Marine animals through GM test, which can be an early, rapid and accurate diagnostic index, and has high clinical application value.

Key words: Galactomannan test, Aspergillosis, Marine animals, Early infection, Clinical application

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