关键词: 小家鼠 , 动物地理区, 基因频率

Abstract: Using biochemical markers， mterocytotoxieity test and Ouchterlony methods，the enetic character of 156 wild mice (Mus musculus)from 6 sites in 4 zoographical egions of China were investigated，and Comparison with 2 strains of laboratory mouse ere studied by authors． he resuIts showed in 13 tested loci are some characteristic getles in 7 Iocli Mus musculus which are rare in laboratory m ouse． The genetic character of Musculus from different zoogeographicaI regions and sabregtons were also different．The importance of introducing the characteristic genes of Mus musculusinto Iabo ratory ollse and breeding new strains was indieated．The effect of Mus musculuswhen breecling mbred and oatbred strains， the difficulties of producing laboratory mouse from us musculus reasons and oountermea sures for homozygosity in some loci of M us musculus． the theoretical significanee and practical significance of comparative study the genetic character of Mus musculus and laboratory nloase were discursed.

Key words: Mus musuculus, Zoogeographical regions, Gene frequency