关键词: 促肾上腺皮质激素释放因子, 去甲肾上腺素, IgG 抗体, 免疫调节

Abstract: What action the CRF and NE played in modulating immune function in the brain of Ochotona curzoniae was studied. The changes of humoral immune function of Ochotona curzoniae were examined by icv injection of CRF, NE and their blocker. The results showed that icv CRF (110 Lg) resulted in a 29.2% (P < 0.01) decrement in the production of IgG; Central administ ration ( icv) of the CRF an tagonist-helical CRF- (9-41) 50ug completely blocked the immunosuppressive action of CRF, when animal were icv injection of NE 5 nM produced a significant suppression of the IgG production. After destroyed central sympathetic nervous system with 6-OHDA , the IgG levels increased by 24.3% (P < 0.01). These findings suggest that enhanced CRF level in the brain might be a source to reduce humoral immune function and central sympathetic nervous system may play a strained suppressive role in modulation of humoral immune in Ochotona curzoniae.

Key words: Corticotroph in releasing factor, Norepinephrine, IgG antibody, Immunoregulation