关键词: 炔雌醚, 布氏田鼠, 不育剂量, 繁殖指标

Abstract: It is critical to confirm the optimum dose and the active duration of the sterilization by quinestrol on rodents for some studies and practices. We fed female and male Brandt’s voles 5 doses of 0. 5 mg// kg,1.0 mg// kg,2. 0 mg// kg, 3. 0 mg// kg,or 6. 0 mg// kg quiestrol for 7 consecutive days．We then assessed their anti-fertility effects on the voles by analyzing reproduction indices including birth date,reproductive rate and reproductive capacity. Results showed that quinestrol delayed the breeding of Brandt’s voles in the lab,but the effect was not significant due to the small sample size. In 90 days,some doses of quinestrol decreased the reproductive rate and average litter size of female and male,however,the inhibitory effect still was not significant,again possibly due to small sample size;some doses of quinestrol decreased markedly the reproductive capacity of Brandt’s voles. The suppression effects were not significantly correlated with the doses of quinestrol. The optimum doses of quinestrol causing sterility were below 2. 0 mg// kg for male and 1. 0 mg// kg for female. The dose applyed for Brandt’s vole should be below 2. 0 mg// kg,which can reduce total litter size of Brandt’s vole obviously within 90 days.

Key words: Brandt’s voles (Lasiopodomys brandtii), Optimal dose, Quinestrol, Reproduction indices