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C0MPARATIVE STUDIES 0N THE ADRENAL C0RTEX ULTRASTRUCTURE AND THE FUNCTI0N 0F MARMOTA HIMALAYANA

CHEN Qinming, YE Yucong   

  • Online:2006-07-29 Published:2007-09-13

不同年龄喜马拉雅旱獭肾上腺皮质超微结构与功能的比较研究

陈钦铭, 叶于聪   

  1. 中国高原医学科学研究院,西宁

Abstract: This paper reports 24 unhibernaton Marmota himalayana which were reared in
temperature 5- 20℃ room of altitude 3 300 m district.The authors divide it into threeage groups(juvenile,adult,old).Adrenal weight,the cholesterol contents of adrenal,the plasma level of hydrocortisone and aldosterone,the variation of mitochondria, lipid droplets and Golgi apparatus of zona glomerulosa as well as the ultrastructurc of thezona glomerulosa, zona fasciculate and zona reticularis of adrenal cortex were determind respectively.
The results indicated the comparison between the old and juvenile or the old andadult presented the decrease of AW/BW ,the decrease of adrenal cholesterol contents(see table 1),the decrease of hydrocortisone and aldosterone in plasma level (see table2),the decrease of number and size of mitochondria,lipid droplets,Golgi apparatus inzona glomerulosa (see table 3). The synthesis of adrenocortical hormone was depenedmainly the esterase in SER and lysosomes in the cytoplasm ,the synthesis functiondecreased and the zona reticularis presented degeneration in the old.

Key words: Marmcta himalayana, Adrenal cortex, Ultrastructure, Cholesterol, Hydrocortisone, Aldosterone

摘要: 本文报道了饲养于海拔3 300米地区,室温5—20℃未冬眠的24只喜马拉雅旱獭(幼年、成年与老年)肾上腺的某些生理参数、肾上腺内胆固醇含量、血浆中皮质醇与醛固酮水平、肾上腺皮质球状带、束状带、网状带超微结构特点,以及应用立体计量分析方法,对3个年龄组的球状带细胞线粒体、脂滴与高尔基复合体的体积密度进行了比较分析。结果表明:老年组与幼年组和成年组相比,上述各项指标数值均下降,且有显著性差异;其皮质激素合成方式则以经滑面内质网或溶酶体的酯酶作用为主,且功能有所减退;其网状带结构呈现衰老、变性征象。

关键词: 喜马拉雅早獭, 肾上腺皮质, 超微结构, 胆固醇, 血浆皮质醇, 血浆醛固酮