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EFFECT 0F ALTITUDE HYPOXIA 0N CAROTID BODY ULTRASTRUCTURE IN MARMOTA HIM ALAYANA,OCHOTONA CURZONIAE AND HILLTOP SPRAGUE DAWLEY RAT

CHEN Qinming, YE Yucong, WEN Jialin   

  • Online:2006-07-29 Published:2007-09-13

高原低氧对喜马拉雅阜旱獭、高原鼠兔缺氧敏感大鼠颈动脉体超微结构的影响

陈钦铭, 叶于聪, 温佳林   

  1. 青海省高原医学科学研究所

Abstract: This investigation reveals with the ultrastructural effects hypoxia in native plateau species Marmota himalayana (3300m above sea leve1), Ochotona curzoniae(3300m ) and plateau-migrated rats (the fourth filial generation of the Wistar rats imported to Xining and migrated to 3300m ),and the Hilltop Sprague Dawley rats divided into 2 groups:(1)quickly brought to altitude (3300m ).(2)remained in Shunghai(contro1).Their left and right carotid bodies were investigated with transmission electron microscope and scanning electron microscope.
There were an increase in the number of type I cells,decrease in the number of dense-cored vesicles,degenerated mitochondria.an increase in number and size of the vacuoles,decrease in the synaptic vesicle of the nerve endings and reduced microtriches in the surface of type I cell in the Sprague Dawley altitude-brought rat.however,no change had been observed in these indexes mentioned above in native 0.curzoniae and M.himalayana at the same experimental conditions.T be 1ight damage of hypoxia of carotid bodies was observed in plateau-migrated Wistar rats.

Key words: Himalayan mormot, Plateau pike, Hilltop sprague-dawley rat, carotid body, Ultrastructure

摘要: 应用扫描电镜结合透射电镜技术,对上海(海拔l0米)的大鼠,5天内从上海急进到海拔3300米的大鼠,由北京引入西宁的子4代大鼠,同高原的喜马拉雅旱獭和高原鼠兔的颈动脉体微细结构进行对比观察。结果表明,高原低氧环境使由低海拔急进到高海拔的大鼠颈动脉体I型细胞增生、肿胀、体积增大,胞浆中裂密核心囊泡数量减少,线粒体变性肿胀,神经末稍突触囊泡减少,I型细胞表面微绒毛变性脱落;而喜马拉雅旱獭和高原鼠兔对高原低氧环境有较好的适应,来见缺氧损害征象。

关键词: 喜马拉雅旱獭, 高原鼠兔, 缺氧敏感大鼠, 颈动脉体, 超微结构