Abstract: The changes of the liver oxidative phosphorylation and respiratory control of rat and O. Curzoniae during acute and chronic hypoxia were investgated with exygen electrode method in this paper．After exposed to hysioxia for 24 hours，in both of the groups of rat and 0．curzoniae at an altitude of 5 and 8 kilometers the oxidative phosphorylation shows no change，and the same for the respiratory control in group of0．curzoniae at thesame time．the rat's respiratory control of two hypoxia groups markedly increases，but this increase is induced by the reduetion of V₄．
When exposed to hypoxia for 25 days，the oxidative phosphorylation in both of rat and 0．curzoniae has not changed yet．There is all obvious reduction in the respiratory control of rats at an altitute of 7 kilometers ald at the same time．an increazed respiratory control in group of O．curzoniae at an altitude of both 5 and 7 kilometer . It is concluded that in the cellular respiratory level, If exposed to hypoxia condition, the 0.curzoniae can use the oxygen more efficiently than rats．

Key words: Ochotona curzoniae, Rat, Oxidative phosphorylation, Respiratory control rate RCR, Hypoxia

摘要： 本实验用氧电极法测定在急性及慢性低氧条件下，S.D大白鼠及高原鼠兔(0chtona -curzoniae)肝线粒体的氧化磷酸化效率及呼吸控制率之变化。结果表明；大白鼠和高原鼠。兔经24小时急性低氧暴露后，其氧化磷酸化效率无明显变化；呼吸控制率在高原鼠兔中无明显变化，而在大白鼠中却有明显增加，这种增加是由于呼吸状态Ⅳ呼吸速度降低而引起的。经25天的慢性低氧暴露后．大白鼠和高原鼠兔的氧化磷酸化效率仍无明显变化，但大白鼠在海拔7000米时的呼吸控制率则有明显下降，而高原鼠兔却明显增加．实验结果提示：在细胞呼吸水平方面，高原鼠兔对低氧的耐受力明显高于大鼠。

关键词: 高原鼠兔, 大鼠, 氧化磷酸化, 呼吸控制率, 低氧