Abstract: The effects of estradiol on the size and secretion chemistry of flank glands in female ratlike hamsters (Cricetulus triton) were studied. By surgical procedure and hormone replacement，three groups of hamsters being different in reproductive status were formed，which were ovariectomized (OF),intact (IF) and overiectomized plus estradiol cap sides females(OEF).From OF to OEF, blood levels of estradiol determined by radioimmunoassay was getting higher (P<0.01),while the weight, length, width and thickness of flank glands were getting less(P<0.05 or P<0.01) by groups. Gas chromatography was usedto measure the differences in flank gland secretions among three groups of hamsters.It was found that there were qualitative and quantitative changes among chemical compounds of flank gland secretions of three groups. Some compounds have a decrease in quantity from OF to 0EF，and less and less compounds were detected from OF to OEF.The results evidenced that estradiol can inhibit both size and secretion activity of flank glands.

Key words: Ratlike hamster(Cricetulus triton), Estradiol, Flank gland, Morphology Chemistry

摘要： 通过研究发现雌二醇对雌性大仓鼠(Cricetulus triton)胁腺的大小和分泌活动存在明显的抑制作用。利用生理手术, 形成3组不同内分泌状况的鼠: 卵巢切除(OF)、正常(IF)、和卵巢切除后又置入雌二醇硅胶管 (OEF) 的雌性大仓鼠; 经过放射免疫方法测定表明由OF、IF到OEF 鼠血液雌二醇的浓度显著增高(P <0.01), 胁腺的重量、长度、宽度和厚度也显著减小(P< 0.05或P <0.01); 利用气相色谱对胁腺分泌物的分析发现, 从OF、IF到OEF鼠的胁腺分泌物的种类逐渐减少 , 有些成分尽管在 3 组不同生理状况的鼠中都存在, 但含量依次明显减少。以上结果表明雌二醇不仅能够抑制胁腺大小的增长, 而且也抑制了胁腺的分泌活动,从而减少了胁腺分泌物或其中某些成分的分泌量。

关键词: 大仓鼠, 雌二醇, 胁腺, 形态, 化学