Abstract: There were low serum T₃ and T₄ concentration and the activities of T₄5'-deiodinase in liver and brown adipose tissue (BAT) in Mongolian gerbil (Meriones unguiculatus), at 22±2℃ of room. Serum T₃ and T₄ concentration increased rapidly after cold exposure(4±2℃ ) for 1 day, both of which showed as 340% and 208% high, respectively, as those in warm. Following cold acclimation from 1 week to 4 weeks, serum T₃ level rose slowly and T₄ decreased slowly, leading to the increase of T₃ /T₄. The changes in T₄5’-deiodinase activities of BAT and liver were similar to those of serum T₃ and T₃ /T₄ during cold exposure. These results indicated that thyroid activity and the metabolism of thyroid hormone in peripheral tissue were activated by cold acclimation in Mongolian gerbil, which may take part in regulation of basal metabolic rate and nonshivering thermogenesis.

Key words: Mongolian gerbil (Meriones unguiculatus), Triiodothyronine, Thyroxine, T45'-deiodinase

摘要： 22℃室温中的长爪沙鼠血清T₃和T₄浓度较低，肝脏和褐色脂肪组织（BAT）的T₄5'-脱碘酶活力也较低。冷暴露（4℃）1d 后，血清T₃与T₄浓度迅猛增长，随后1-4周的冷驯化中，T₃缓慢上升，T₄逐渐下降，肝脏和BAT 的T₄5'-脱碘酶活力变化与血清T₃和T₃\T₄变化一致。表明冷驯化激活了甲状腺功能，激活了外周组织中的甲状腺激素代谢。

关键词: 长爪沙鼠, 甲状腺素, 三碘甲腺原氨酸, T45'-脱碘酶