Abstract: RH-945 is 3-pyridylmethyl-N-(4’-nitrophenyl) Carbamate.DLP-787 is l-(3-pyridylmethyl)-3-(4’-nitrophenyl) Urea.Killing rats ratio of 1% RH-945 poison bait are 88.86±6.97%, and 1% DLp-787 poison bait are 79.51±3.46% in the house. Killing rats ratio of 1% RH-945 poison bait are 80.26±7.80%, and 1% DLP-787are 85.00±6.99% in the field.We had considered that naicotionamide can detoxify to RH-945 and DLP-787,because it is hydrogen-acceptor of DPN and TPN, and it is absolutely necessary matter in biological oxidation.

摘要： 灭鼠安、灭鼠优是70年代出现的新单剂量灭鼠剂。国外经试验对多种鼠有杀灭效果,适口性较好,对非杀灭对象比较安全,对抗凝血剂有耐药性的鼠能够杀灭等优点。国内军事医学科学院等单位也有合成,我站在1978—1979年对这两类药进行了现场灭效和解毒试验,并对毒理机制进行了探讨,今报告如下。