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| The effect of coccidian infection on immune function of root voles (Microtus oeconomus) ：a field experiment |
| SHANG Guozhen 1,2, WU Xueqin 1,2, ZHU Yahui 1,2, CAO Yifan 1,4, WU Yan 1,3, BIAN Jianghui 1,4 #br# |
(1 Key Laboratory of Adaptation and Evolution of Plateau, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810001, China)
(2 University of Chinese Academy of Sciences, Beijing 100049, China)
(3 School of Life and Environment Sciences, Hangzhou Normal University, Hangzhou 310012, China)
(4 Qinghai Key Laboratory of Animal Ecological Genomics，Xining 810001, China)
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Abstract The immune function of animals is an important factor to affect the fitness of animal. In this study, we measured phytohemagglutinin (PHA) response, anti-keyhole limpet hemocyanin immunoglobulin G (anti-KLH IgG) level and hematological parameters of root voles (Microtus oeconomus) by controlling infection of coccidioides in the enclosure to study the effect of coccidian infection on immune function. Our results show that coccidian infection treatment significantly increased the prevalence and intensity of coccidia during the experiment, and significantly reduced the PHA response, serum anti - KLH IgG levels, white leukocyte counts, the percentage of lymphocytes, and plasma protein concentration in root vole. And infection treatment significantly increased the percentage of basophils, the significant difference between both treatments in percentage of eosinophils, neutrophils and monocytes were not found. These results indicate that coccidian infection has negative effects on the cell mediated immune response and humoral immune response of root voles.
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