%0 Journal Article %A CHEN Xiaofen %A HUANG Zelin %A LIANG Shuyu %A SHEN Bo %A ZHANG Delu %A ZHANG Peng %A ZHANG Xiaomin %A DONG Guixin %T Clinical application of galactomannan test in early diagnosis of aspergillosis in captive marine animals %D %R 10.16829/j.slxb.150592 %J ACTA THERIOLOGICA SINICA %P 339-344 %V 42 %N 3 %X Aspergillosis is one of the most common diseases in captive marine animals, and the early diagnosis of infection has not been reported. Galactomannan (GM) test is a good method for Aspergillus detection, which has a high clinical value in the early diagnosis of human medical Aspergillus infection, and can significantly improve the detection rate of Aspergillus patients. The purpose of this study was to investigate the clinical value of the GM test in the early diagnosis of aspergillosis infection in captive marine animals. The serum of 106 captive marine animals was tested for GM antigen, 25 were positive and 81 were negative. The dynamic changes of GM antigen levels before and after antifungal treatment were detected in 21 positive individuals. In addition, clinical data of the infected animals were collected for statistical analysis, and the value of GM detection for the early diagnosis of Aspergillus infection in captive marine animals was evaluated. When single I ≥ 0. 7 was used as the positive threshold for sea mammals and single I ≥ 1. 2 as the positive threshold for seabirds, the results showed that the sensitivity and specificity of the test were 91% for sea mammals and 94% for seabirds. This study shows that the GM test can effectively reflect the degree of Aspergillus infection in captive Marine animals through GM test, which can be an early, rapid and accurate diagnostic index, and has high clinical application value. %U http://www.mammal.cn/EN/10.16829/j.slxb.150592