关键词: 大绒鼠, 禁食, 重喂食, 体重, 产热, 血清瘦素

Abstract: The adaptive control of animal behavior and physiological activities is the main strategy in response to the change of food resources. To investigate the effect of fasting and refeeding on the body mass,thermogenesis and serum leptin in Eothenomys miletus,changes in body and body fat mass,resting metabolic rate (RMR),body composition,serum leptin level and post-fasting food intake were monitored and measured. The data showed significant fasting-induced reductions in body mass and body fat mass. Body mass,but not body fat,can be restored to the control level in refeeding voles. RMR decreased significantly in response to fasting,and can return to the control level after refeeding. Fasting for 12 hours induced a rapid reduction in serum leptin content,it can not recover the control level after refeeding. Interestingly,there were no postfasting compensatory increases in food intake. There was a positive relation between serum leptin level and body fat mass. Our data indicate that E. miletus can adjust their physiological functions integratively to cope with starvation by decreasing body mass,adaptive thermogenesis and serum leptin level. There is no post-fasting hyperphagia in E. miletus. The reduction of serum leptin was somewhat earlier than the decline in body fat and body mass.

Key words: Body mass, Eothenomys miletus, Fasting, Refeeding, Serum leptin, Thermogenesis