Wildlife resources are essential for biodiversity monitoring and conversation management in protected areas. From September 2013 to November 2014, we conducted a camera-trapping survey to investigate ground-dwelling mammals and birds in the Longxi-Hongkou National Nature Reserve, Sichuan Province. During the 11,846 camera-days, we recorded 21 mammal species and 40 bird species with Falco cherrug, Zoothera mollissima, Zoothera dixoni, Turdus boulboul, Pomatorhinus erythrogenys, Conostoma aemodium and Paradoxornis unicolor as new bird records in the nature reserve. Four mammal species were listed as Class I state-key protected wild animals and five as Class II. Three mammal species were evaluated as Endangered by IUCN Red List, three as Vulnerable and four as Near Threatened. Five bird species were listed as Class II state-key protected wild animals and one bird specie evaluated as Endangered by IUCN Red List. This study replenishes and renews animal lists on ground-dwelling birds of Longxi-Hongkou National Nature Reserve. This study provides basic information for establishing camera-trapping routine survey and conservation management for large and medium-sized mammal and bird species in the natural reserve.