Journal articles on research field of mammals respond to climate changewere analyzedusing the Thomson Data Analysis based on Zoology Record Database. Development trajectory of research on the field from different mammalian species, different geological times, research hotspot distribution and evolution of research focus of difference periods were analyzed. The field of mammals respond to climate change is rapidly developingfrom 2000y.There is strong response relationshipbetween the research hotspot and species of mammals. Different species of mammals corresponding geological timewere showed subtle changes. Some new research hotspot presented frequently are population dynamics, conservation, arctic ecology instead of fossil assemblages and evolution in last 5a.