In Fanjingshan National Nature Reserve, Guizhou, China, the spatial distributions of Rhinopithecus brelichi and Macaca thibetana are overlapped. In order to understand their competive coexistence relationship, camera traps were set up, from April 2017 to January 2019, to monitor the Rhinopithecus brelichi and Macaca thibetana in the area. The difference of habitat selection between Rhinopithecus brelichi and Macaca thibetana in different seasons was analyzed by using Occupancy model. The results show that Rhinopithecus brelichi and Macaca thibetana mainly distribute in the evergreen and broad-leaved, deciduous forests in the mid-alpine region, with occurrence rate of 0.85 and 0.65, respectively. Though Rhinopithecus brelichi mainly appear above 1500 m altitude. The simulation by utilizing Occupancy model suggest that during the summer, Rhinopithecus brelichi prefer evergreen and broad-leaved, deciduous forest in the mid-alpine region with lower human disturbance; and the Macaca thibetana prefer to live in other forest types. Both species show spatial avoidance (SIF = 0.87). During the winter, Rhinopithecus brelichi and Macaca thibetana prefer to live at lower altitude, with a spatial overlap of SIF = 1.09. In conclusion, the available habitats of Rhinopithecus brelichi and Macaca thibetana keep change with season, which urge them to develop a spatial coexistence strategy. Meanwhile, this study provides management department with scientific data for effective protection of Rhinopithecus brelichi and Macaca thibetana.