Chongzuo White-Headed Langur National Nature Reserve is a typical karst landscape with abundant wildlife. In order to assess the status of large and medium-sized mammals and forest birds in the reserve, 60 infrared camera traps were set in the Tuozhu area of the reserve for continuous monitoring. Based on 4848 independent photographs collected from January 2017 to January 2018, we identified 16 mammal species and 29 bird species，including two Class Ⅰ and four Class Ⅱ state key protected animals. Based on a relative abundance index, Leopoldamys edwardsi , Melogale moschata, Tupaia belangeri, Sus scrofa and Herpestes urva were ranked as the five most abundant mammal specices．Lophura nycthemera, Pitta soror, Myophonus caeruleus and Gorsachius melanolophus were ranked as the four most common bird species. Leopoldamys edwardsi and Melogale moschata were predominantly nocturnal, while Sus scrofa , Herpestes urva , Lophura nycthemera and Pitta soror were mostly diurnal. There was no significant difference in species number and species diversity index between core zone, buffer zone and experimental zone. Our results provide preliminary data for species composition of large and medium-sized mammals and forest birds, their relative abundances, and spatial distributions in Chongzuo Reserve. This data is important for future research and protection management.