ORIGINAL PAPERS

Effect of interscapular brown adipose tissue removal on immune function in female striped hamsters

  • XU Deli ,
  • WANG Yi ,
  • ZHANG Xueying ,
  • WANG Dehua
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  • 1 Shcool of Life Sciences, Qufu Normal University, Qufu 273165, China;
    2 State Key Laboratory of Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;
    3 Shcool of Life Sciences, Shandong University, Qingdao 266237, China

Received date: 2024-07-31

  Revised date: 2024-11-26

  Online published: 2024-11-26

Abstract

In order to understand the effect of thermogenic capacity on immune function in animals, female striped hamsters (Cricetulus barabensis) were randomly assigned into the warm interscapular brown adipose tissue (IBAT) sham-removed group (WS, n = 5), the cold IBAT sham-removed group (CS, n = 7), and the cold IBAT removed group (CS, n = 8). IBAT removal or gradually decreased temperature had no effect on body mass and body composition. However, low temperature reduced total body fat mass. IBAT removal did not affect organ wet masses including liver, thymus, and spleen, indicating there was no trade-off between thermogenesis and immunity at organ size levels. However, gradually decreased temperature increased the wet mass of small intestine and colon, the length of small intestine and total digestive tract, indicating the increase of the food processing and digestive capacities to satisfy the enhancement of energy requirements under the condition of low temperature. IBAT removal or gradually decreased temperature had no influence on the wet mass of thymus and spleen, the maximal phytohaemagglutinin (PHA) response, as well as the number of white blood cells, lymphocytes, intermediate granulocytes, and neutrophil granulocytes, suggesting that no trade-offs relationship might occur between immune function and thermogenic capacity. In summary, IBAT removal or gradually decreased temperature had no effect on immune function in striped hamsters.

Cite this article

XU Deli , WANG Yi , ZHANG Xueying , WANG Dehua . Effect of interscapular brown adipose tissue removal on immune function in female striped hamsters[J]. ACTA THERIOLOGICA SINICA, 2025 , 45(4) : 457 -467 . DOI: 10.16829/j.slxb.150989

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