The prospective applications of single-cell transcriptome sequencing in mammalian inner ear research
Received date: 2025-01-23
Accepted date: 2025-04-27
Online published: 2025-04-27
The inner ear, as the core organ responsible for hearing and balance, possesses an intricate structure with diverse cell types. Single-cell RNA sequencing technology (scRNA-Seq) enables the capture and analysis of gene expression profiles at the individual cell level, providing a powerful tool for in-depth exploration of the functions and molecular mechanisms of the inner ear. We review the significant applications of scRNA-Seq in inner ear research from 2015 to 2024, highlighting important advances in revealing cellular heterogeneity, tracing inner ear development processes, investigating hearing loss mechanisms, and cell regeneration researches. We also discuss the potential application of scRNA-Seq technology in addressing key scientific questions in wildlife research and explore the prospects of single-cell multi-omics techniques in uncovering the adaptive evolution and molecular mechanisms of the mammalian inner ear.
Mengdie ZHANG , Bicheng ZHU , Guanglin HE , Yuzhong ZHANG , Jinchan JIAN , Anqi SHEN , Yunzhu LIU , Kai HE . The prospective applications of single-cell transcriptome sequencing in mammalian inner ear research[J]. ACTA THERIOLOGICA SINICA, 2025 , 45(6) : 771 -783 . DOI: 10.16829/j.slxb.151059
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