Abstract：In this study, Mongolian gerbils were randomly divided into multi-dose treated group (MDT group),one-dose treated group (ODT group)and control group (CK group) to explore effects of quinestrol on reproductive organs and reproduction. The epididymides, eminal vesicles and semen quality, fertility were assessed at 15,30,60 and 90 days after treatment. Histopathological changes of epididymides were observed by H. stain. Results showed that the coefficient of testes, pididymides,and seminal vesicles were significantly decreased (P < 0.01)at 15 or 30 days after treatment. The normal function of the sex gland was impaired, hich led to significant decrease in the density and amount of live spermatozoa and reproductive rates (P < 0. 01),as well as a significant increase of abnormal spermatozoa (P < 0.01) in both MDT group and ODT group. Compared with the ODT group, the damage for gerbil reproduction in MDT group was more severely at 15 or 30 days after treatment (P < 0. 01). After 60 days of treatment withdrawal, the sex gland in treated group was normalized except for gerbil epididymides in the MDT group, while semen quality and reproductive rates were still lower than those in the control group (P < 0.01). The physiological indicators were recovered by 90 days of treatment withdrawal. This indicates that quinestrol shows certain effects on reducing the fertility of male gerbil with a reversible effect after 90 days’treatment and multi-dose treatment has more effects to infertility compared with one-dose treatment.
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