ACTA Theriologica Sinica

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Effects of maternal density stress and coccidiosis infection on immunity in root vole offsprings

ZHANG Xin, YANG Yanbin, DU Shouyang, CAO Yifan, BIAN Jianghui   

  1. Northwest Institute of Plateau Biology, Chinese Academy of Science
  • Online:2018-01-30 Published:2018-04-09


张鑫 杨彦宾 堵守杨 曹伊凡 周华坤 边疆晖   

  1. 中国科学院西北高原生物研究所
  • 通讯作者: 边疆晖 E-mail:
  • 基金资助:

Abstract: The immune function of animal is an important factors to influence animal  fitness. As it is a crucial way to defend against bacterial pathogens such as viruses, the immune system play a key role in animal’s survival. Both population density and parasitization are known to deteriorate individuals’ immune function. This experiment using 2×2 factorial experiment design to measure the indexes of four treatments(maternal density stress+coccidian infection, not maternal density stress+not coccidian infection, maternal density stress+not coccidian infection, not maternal density stress+coccidian infection), including the fecal corticosterone metabolite(FCM), coccidian infection rate,blood parameters, lymphocyte subsets counts(CD4, CD8 counts). The results show that the density-induced maternal stress can significantly reduce the number of CD4, rate of CD4/CD8, Lymphocytes, Eosinophils, white cell. The effects were further deteriorated when maternally stressed offspring infected with coccidian. Our results showed that the interaction of density-induced maternal stress and coccidian infection has negatively synergistic effect on the immune of root vole.

Key words: Coccidian, Lymphocyte subsets, Maternal stress, Root voles

摘要: 免疫功能是影响动物个体适合度的重要因素之一,也是防御病原体入侵的重要途径,对动物的生存至关重要。种群密度与寄生物感染都能影响动物的免疫功能。本实验通过2×2析因实验设计,测定了母体密度应激+球虫感染、母体密度应激+未球虫感染、未母体密度应激+球虫感染、未母体密度应激+未球虫感染等4个处理对根田鼠粪便皮质酮、球虫感染率、白细胞总数、各型白细胞的百分比、淋巴细胞亚型计数(CD4,CD8计数)等指标。结果表明,高密度母体应激处理可显著降低CD4数量、CD4/CD8比例、淋巴细胞数、嗜酸性粒细胞数、白细胞数,母体应激与球虫的耦合可使上述免疫指标进一步降低,说明母体密度应激和球虫感染对于根田鼠的免疫具有负的叠加效应。

关键词: 根田鼠, 母体应激, 球虫, 淋巴细胞亚型