Abstract: The paper represented comparisons of content of glycongen in myocardium, skeletal muscle and cerebral cortex and the concentration of blood sugar between ratsand plateau mammals pika(ochotona curzoniae)atdifferent ages during simulated altitude hypoxia. It was found that the myocardiym and skeletal muscle glycogen in aged rats increased after exposed to an elevation of 8000m for 24h. while the content of cerebral cortex had no change. The glycogen levels of the myocardium, skeletal muscle and cerebral cortex in all adult rats were enhanced with rise of altitude. When rats were exposed to hypoxia at the altitiude of 7000m for 25 days ,the glycogen level of cerebal cortex in both aged and adult rats had a little of increase, but that of skeletal muscle and myocardium increased significantly, the blood sugar concentration in rats had no significant changes during exposure to hypoxia fo 48h. and 7days. After thd adutl O.curzoniae were exposed to hypoxia for 24h.the gocogen of cerebral crtex reduced markedly at either 5000 or 8000 altitude. the myocardium goycogen rose at an altitude of 8000m ,while the skeletal muscle glycogen reduced a little withe rise of altitude. In young O.curzoniae, cerebral cortex goycogen reduced and myocardium and skeletal glycogen increased with rise simulated altitide. The blood sugar in both young and adult O.curzoniae rose with the elevation enhancing and effect at 8000m was much more potent than that at 5000m.

Key words: Rat, Ochotona curzoniae, Hypoxia, Glycogen content, B1ood sugar concentration)

摘要： 比较不同年龄组大鼠和高原鼠兔(Ochotona curzoniae)的心肌、骨骼肌和脑皮层组织的糖原含量，以及血糖浓度在模拟高原低氧的变化，发现急性高原低氧暴露24小对，老年组大鼠心肌、骨骼肌糖原含量在海拔8000米高度时有不同程度升高。血糖水平在8000米高度也有明显上升。成年组大鼠心肌、骨骼肌和脑皮层组织糖原含量随海拔升高而增加。慢性低氧暴露25天，大鼠脑组织糖原含量在海拔7000米耐略有升高，心肌和骨骼肌糖原含量在海拔7000米时明显升高。低氧暴露7天和48小时，大鼠血糖浓度无明显变化。
高原鼠兔在急性低氧暴露期间，成年组脑糖原含量在海拔5000米和8000米高度时均有明显下降，心肌糖原在8000米高度时明显升高。骨骼肌糖原含最随海拔升高而略有降低。幼年组高原鼠兔脑糖原含量随海拔升高而下降，心肌和骨骼肌糖原在海拔升高时有增加倾向。成年和幼年组鼠兔血糖水平则随海拔上升而升高。

关键词: 大鼠, 高原鼠兔, 低氧, 糖原含量, 血糖浓度