关键词: 中缅树鼩, 噪音, 行为, 学习记忆, 氧化应激

Abstract: In order to investigate the effects of noise stimulation on behavior,learning and memory and oxidative stress in Tupaia belangeri,body mass,food intake,behavioral changes,the ability of learning and memory,and concentrations of Malondialdehyde(MDA),Superoxide dismutase(SOD),Acetylcholinesterase(AChE) concentration,Nitric oxide synthase(NOS),activities of SOD,AChE and NOS in brain under the condition of constant stimulation 8 hours for 0 dB,40 dB and 80 dB noise last for 28 days,respectively.The results showed that different noises had different effects on body mass in T. belangeri. Body mass showed significant differences among three groups on day 28,which was lower in 80 dB group. Variation trend of food intake was similar to that of body mass changes. Higher noise intensity reduced feeding and activity behavior significantly in T. belangeri,and increased rest behavior,but had no significant effect on modification behavior. On day 28,there was a significant difference in the correct response rate among three noise groups;the correct reaction rate was lowest under the condition of 80 dB. The influence of different noises intensity on MDA concentration,SOD concentration and AChE concentration were significant,among which the concentration of MDA and SOD were higher and the concentration of AChE was lower in 80 dB group. Different noises intensity also affected NOS concentration,NOS,SOD and AChE activities significantly,among which SOD activity was higher,while NOS concentration,NOS and AChE activities were lower under the condition of 80 dB. All of the above results suggested that higher noise intensity reduced body mass,food intake,feeding behavior and activity behavior,increased rest behavior,and induced the cognitive impairment in T. belangeri. Moreover,intense noise stimulation increased oxidative stress and different degrees of oxidative damage in brain of T. belangeri.

Key words: Tupaia belangeri Noise, Behavior, Learning and memory, Oxidative stress