关键词: 寄生物, 免疫功能, 球虫, 种群调节, 根田鼠

Abstract: The immune function of animals is an important factor to affect the fitness of animal. In this study, we measured phytohemagglutinin (PHA) response, anti-keyhole limpet hemocyanin immunoglobulin G (anti-KLH IgG) level and hematological parameters of root voles (Microtus oeconomus) by controlling infection of coccidioides in the enclosure to study the effect of coccidian infection on immune function. Our results show that coccidian infection treatment significantly increased the prevalence and intensity of coccidia during the experiment, and significantly reduced the PHA response, serum anti - KLH IgG levels, white leukocyte counts, the percentage of lymphocytes, and plasma protein concentration in root vole. And infection treatment significantly increased the percentage of basophils, the significant difference between both treatments in percentage of eosinophils, neutrophils and monocytes were not found. These results indicate that coccidian infection has negative effects on the cell mediated immune response and humoral immune response of root voles.

Key words: Parasites, Immune function, Coccidia, Population regulation, Root vole(Microtus oeconomus)