关键词: 敌溴灵, 吸收, 消除, 药物动力学

Abstract: After oral administration of desmethylbromethalin to rats, the blood concentration of desmethylbromethalin was determined by HPLC，and the pharmacokinetic parameters 0f the compound were obtained．The experimental results indicated that desmethylbro-methalin is quickly absorbed in rats and then slowly eliminated from blood.The peak of serum concentration is reached in 2.15 hours after oral administration．The absorption half life is 0.32 hour and the elimination half life is 31.94 hours．Low concentration bait(50 ppm) of desmethy lbromethalin is pa latable and several feedings of the bait may be maintaining the lethal concentration in blood on target animals．However if properly used，it is safer to nontarget animals than other acute rodenticides．

Key words: Desmeth lbromethalin, Absorption, Elimination, Pharmacokineties