关键词: 黄毛鼠, 卡麦角林, 睾丸, 酸性磷酸酶, 乳酸脱氢酶

Abstract: To investigate the effects of cabergoline dosage and duration on the reproductive system of normal male animals, forty male rats were randomly divided into five groups and treated with cabergoline for 3 consecutive days at varying doses (0, 50μg/kg, and 100μg/kg)． Rats from T750 and T7100 were sacrificed by decapitation on 7 d after cabergoline administration, and those from T2450 and T24100 were sacrificed by decapitation on 24 d after cabergoline administration We then observed changes in testicular tissue cells and examined the activities of enzymes in testis such as acid phosphatase (ACP),alkaline phosphatase (AKP),lactate dehydrogenase (LDH)and glutathione peroxidase (GSH-Px)by colorimetry. Results showed that endogenous germ, stromal and supporting cells in seminiferous tubules were damaged, or even fell off and disintegrated. Cabergoline treatment at 100 μg/kg decreased the ACP enzyme activity,but it was restored on 24 d after cabergoline administration. Cabergoline did not affect AKP levels. The dose increased will decreased the amount of increasing of LDH enzyme activity, and recovery on 24 d after cabergoline treatment. The activity of GSH-Px was significantly increased at 24 d at 100 μg/kg cabergoline compared with the control group, and more than those in 50 μg/kg group. Hence,cabergoline has some influence on the reproductive system of males, and can significantly affect the activities of enzymes in the testis.

Key words: Acid phosphatase, Cabergoline, Lactate dehydrogenase, Rattus losea, Testis