关键词: 布氏田鼠, 运动, 体重, 瘦素

Abstract: Maintaining a stable body weight requires a balance between energy intake and energy expenditure. Exercise, which can increase energy expenditure, is one of the most important factors affecting energy balance for animals. In order to understand the hysiological effects of exercise,we measured changes in body mass,body fat content,food intake, and serum leptin levels in Brandt' voles(Lasiopodomys brandtii) uring 6-weeks of forced exercise training with of treadmill. Food intake was measuerfwith food trials. Body fat mass was measured with the Soxhlet method. Serum leptin concentration was measured with multispecies RIA kit. The results showed that exercise training decreased serum leptin concentrations by 30% compared with controls and no significant effects on body mass and food intake were detected during 6 weeks exercise training. Body fat decreased by 3. 5 grams in exercise trained voles,but was not significantly different from controls. There is a positive relationship between serum leptin concentrations and body fat content in control voles,but not for exercise trained voles. These results suggest that the decrease in serum leptin levels caused by forced long-term excise training is independent on the changes in body mass and body fat content. Brandt’s voles may mobilize body fat and decrease nonexercise energy expenditure rather than to increase food intake to regulate energy balance during forced exercise training.

Key words: Body fat, Body mass, Brandt's vole(Lasiopodomys brandtii), Food intake, Long-tem forced exercise training