Abstract: This research was carried out from May to August 2011 at the Haibei Alpine Meadow Ecosystem Research Station, Chinese Academy of Science, Qinghai Province. Wild plateau pikas (Ochotona curzoniae) were captured from May to August in order to observe monthly changes in total cholesterol, triglyceride, phospholipid, and high-density lipoprotein cholesterol levels in serum. The serum lipid levels were also examined after the pikas were given various doses of tannic acid for different periods by intragastric administration in July. The results showed that the serum lipids responded differently to tannic acid. The total cholesterol level did not change significantly after administration of tannic acid. The serum triglyceride level decreased sharply after administration of middle and high doses of tannic acid for one day and four days; similarly, the levels of serum phospholipid were lower in both the middle-dose and high-dose groups compared with those in the control group. However, the level of serum high-density lipoprotein cholesterol in the high-dose group was higher than that in the control group after tannic acid administration for one day and four days. In the wild plateau pikas, the serum triglyceride and phospholipid levels increased from May to July, but decreased in August. In contrast, the levels of serum total cholesterol and high-density lipoprotein cholesterol decreased from May to July, but increased in August. A negative correlation was observed between triglyceride and high-density lipoprotein cholesterol. Our results indicate that intragastric administration of some dosages of tannic acid can reduce the triglyceride and phospholipid levels and increase the high-density lipoprotein cholesterol level in the serum of plateau pikas in a short period. The variation in serum lipids observed among the different months may have been related to the nutritional and reproductive conditions of the wild plateau pikas.

Key words: Monthly changes, Plateau pikas (Ochotona curzoniae), Serum lipids, Tannic acid

摘要： 2011年5-8月在中国科学院海北高寒草甸生态系统定位站，用分光光度法测定每月野外捕捉的高原鼠兔和7月份室内灌胃单宁酸的高原鼠兔血清中甘油三酯、磷脂、总胆固醇和高密度脂蛋白胆固醇的水平。结果发现单宁酸对高原鼠兔血清中各种脂类水平有不同的影响。灌服单宁酸后胆固醇水平没有显著变化；中剂量和高剂量组甘油三脂水平在灌胃1天和4天后显著下降；中剂量和高剂量组磷脂水平显著下降；高剂量组高密度脂蛋白胆固醇水平在灌胃1天和4天显著高于对照组。甘油三脂和磷脂水平在5-7月逐渐上升，而8月下降；胆固醇和高密度脂蛋白胆固醇水平在5-7月逐渐下降，而8月上升；甘油三脂水平与高密度脂蛋白胆固醇水平有显著的负相关性。结果表明一定剂量的单宁酸在短期内能降低高原鼠兔血清中甘油三脂和磷脂水平，升高血清中高密度脂蛋白胆固醇水平，而高原鼠兔血脂水平月份间变化可能与高原鼠兔营养水平和繁殖性能相关。

关键词: 单宁酸, 高原鼠兔, 血脂, 月份间变化