ACTA THERIOLOGICA SINICA ›› 2014, Vol. 34 ›› Issue (2): 181-187.

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Diagnosis and treatment of squirrel monkeys infected with Yersinia pseudotuberculosis

ZHOU Ziyao, ZHOU Xiaoxiao, PENG Guangneng, TANG Tianliang, PENG Xi, ZHONG Zhijun, LIU Changsong, LIU Junqing, WU Jianglan, SUN Hongyan, DENG Qiao, ZHOU Zhijin   

  1. College of Veterinary Medicine of Sichuan Agricultural University,
  • Online:2014-05-13 Published:2014-08-18
  • Contact: PENG Guangneng:


周紫峣 周潇潇 彭广能 唐天亮 彭西 钟志军 刘长松 刘俊卿 吴江兰 孙鸿雁 邓乔 周治金   

  1. 四川农业大学动物医学院
  • 通讯作者: 彭广能
  • 基金资助:
    国家自然科学基金面上项目(31272620);教育部“长江学者和创新团队发展规划” 创新团队项目(IRT0848)

Abstract: Six squirrel monkeys died suddenly in an animal park of Ya’an in February 18th to 20th,2013. During that time,~100 squirrel monkeys were infected and had different symptoms which caused significant losses at the zoo. To find the reasons and treatments of this infectious disease,we first examined tissue changes by using anatomy and pathological sections;we then detected pathogens by isolation and culture of bacteria,identified the pathogens by biochemical testing and molecular identification;after that,we searched for the characterizations of pathogenicity and epidemiology through experiments
of animal regression and drug resistance;and finally controlled this disease by a series of emergency measures. The results showed that various monkey’s organs had serious congestion necrosis and severe tissue lesions caused by a large number of bacteria. The pathogen was Yersinia pseudotuberculosis which was similar as Yersinia pestis. The pathogen had strong abilities of pathogenicity,epidemiology and drug resistance,but was sensitive to Amikacin. This is the first study to find and report a case of squirrel monkeys infected with Yersinia pseudotuberculosis in our country,and provides a basis of reference in the diagnosis and treatment,epidemiological studies and pathological model building.

Key words: Isolation and identification, Squirrel monkeys, Yersinia pseudotuberculosis

摘要: 2013 年2 月18 - 20 日,四川省雅安市碧峰峡野生动物园内6 只松鼠猴突然接连死亡,同时约有100 只松鼠猴也出现了不同症状,给动物园造成了严重的损失。为寻找传染病因和治疗防控措施,首先采用尸体剖解和病理切片对其进行了组织学检查,然后采用细菌分离培养和鉴定确定了病原菌,通过动物回归试验和耐药性试验发现其致病性和流行性特征,并采取紧急治疗和防疫措施及时控制了疫情。结果表明,死猴尸体内多处器官发生淤血坏死,组织病变严重并可见大量细菌。经鉴定,分离到的病原细菌为假结核耶尔森菌,该菌与鼠疫耶尔森菌同源性极高,且具有强烈的致病性、传染性和一定的耐药性,对丁胺卡拉霉素较为敏感。这是我国首次发现并报道的松鼠猴感染假结核耶尔森菌病例,本文对其诊断与治疗、流行病学研究和病理模型建立提供了一定的基础参考资料。

关键词: 松鼠猴, 假结核耶尔森菌, 分离鉴定