Abstract: With increasing importance for the understanding aging,epilepsy，the process of domestication and sociobiological questions, the Mongolian gerbil has become a model animal and was used in pharmacological，parasitological, endocrinological, and cancer research. We have been bred Z：ZCLA Mongolian gerbil and is giving bio-purification since 1978, now we have established wo standards closed colony, the conventional colony and the specific pathogen free (SPF) colony.In this paper, we studied the polymorphism of the conventional closed colony of Z：ZCLA Mongolian gerbil with PCR-denatured polyacrylamide gel electrophoresis-silver nitrate staining and recorded their characters. We used 9 microsatellite loci as markers to detect the genetic variation of our colony, and found that locus 1 had only one allele, while locus 2-9 had two to four alleles, respectively. Average heterozygosity, allele number and polymorphism information content (PIC) was recorded as 0.4684, 2.6 and 0.4166,respectively. The individual gene homogeneity was found 0.1111-0.5555, with an average of 0.3389. Therefore, we observed the medium genetic diversity of the conventional closed colony of Z：ZCLA Mongolian gerbil．

Key words: Z：ZCLA Mongolian gerbil, Micrasatellite DNA Markers, Genetic

摘要： 通过对9个微卫星座位的扩增，研究了Z：ZCLA长爪沙鼠的遗传多态性。结果表明，Z：ZCLA长爪沙鼠在其中1个位点上只有一个等位基因，在其它位点上均有2～4个等位基因，平均等位基因数2．6个。平均杂合度0．4684，平均多态信息量0．416 6，平均有效等位基因数2．175 6。全群基因纯合度从0．111 1～0．555 5，平均0．338 9，提示目前本群遗传多样性水平处于中度多态。

关键词: Z：ZCLA长爪沙鼠, 微卫星DNA, 遗传多态性